Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19

Ali AL-Samydai¹ , Maha N Abu Hajleh², Amal Akour^3,4, Naeem Shalan¹, Nisrein Jaber⁴, Lidia Kamal Al-Halaseh⁵, Muhammed Alzweiri⁶

¹Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan; ²Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan; ³Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan, Amman 19328, Jordan; ⁴Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan; ⁵Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak 61710, Jordan; ⁶Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 19328, Jordan.

For correspondence:- Ali AL-Samydai Email: a.alsamydai@ammanu.edu.jo

Accepted: 23 October 2021 Published: 30 November 2021

Citation: AL-Samydai A, Hajleh MN, Akour A, Shalan N, Jaber N, Al-Halaseh LK, et al. Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19. Trop J Pharm Res 2021; 20(11):2387-2393 doi: 10.4314/tjpr.v20i11.22

© 2021 The authors.
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Abstract

Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach.

Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods.

Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R).

Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARS-CoV2 infection.

Keywords: SARS-CoV-2, Docking, Coenzyme Q10, Ubiquinol-10, Idebenone